All Publications:

Peer Reviewed Publications (#=M.S. student, @=undergraduate)

Iosue CL, Ugras JM@, Bajgain Y#, Dottor CA@, Stauffer PL@, Hopkins RA@, Lang EC@, and Wykoff DD. 2023. Pyruvate decarboxylase and thiamine biosynthetic genes are regulated differently by Pdc2 in S. cerevisiae and C. glabrata. PLOS ONE 18(6):e0286744. doi: 10.1371/journal.pone.0286744

Bui LN@, Iosue CL, and Wykoff DD 2022. Tup1 paralog CgTUP11 is a stronger repressor of transcription than CgTUP1 in Candida glabrata. mSphere 7(2) (Editor’s pick)

Giuliano R, Roireau J, Rosano R, Lazzara N#, Bajsa-Hischel J, Chen T, Schrader K, Duke S, & Wykoff D. 2020. Synthesis of Pyranopyrans Related to Diplopyrone and Evaluation as Antibacterials and Herbicides. Journal of Agricultural and Food Chemistry. doi: 10.1021/acs.jafc.0c02564.

Rippel TM#, Iosue CL, Succi PJ, Wykoff DD, & Chapman SK. 2020. Comparing the impacts of an invasive grass on nitrogen cycling and ammonia-oxidizing prokaryotes in high-nitrogen forests, open fields, and wetlands. Plant and Soil 449: pp. 65–77.

Patel K# , Cangelosi C# , Warrier V@, Wykoff D,  & Wilson JW. 2020. The cloned SPI-1 type 3 secretion system can be functionally expressed outside Salmonella backgrounds. FEMS Microbiol Lett. 2020 367(8):fnaa065. doi: 10.1093/femsle/fnaa065.

Iosue CL, Gulotta AP#, Selhorst KB@, Mody AC@, Barbour KM@, Marcotte MJ@, Bui LN@, Leone SG#, Lang EC@, Hughes GH@, & Wykoff DD. 2019. A Novel cis Element Achieves the Same Solution as an Ancestral cis Element During Thiamine Starvation in Candida glabrata. G3 doi: 10.1534/g3.119.400897

Nahas JV@*, Iosue CL*, Shaik NF@, Selhorst K@, He BZ & Wykoff DD. 2018. Dynamic Changes in Yeast Phosphatase Families Allow for Specialization in Phosphate and Thiamine Starvation. G3 pii: g3.200303.2018. doi: 10.1534/g3.118.200303. (*authors contributed equally to work)

Barreto CR#, Morrissey EM, Wykoff DD & Chapman SK. 2018. Co-occurring mangroves and salt marshes differ in microbial community composition. Wetlands. (

Burch J, Mashayekh S, Wykoff DD, & Grimes CL. 2017. Bacterial derived carbohydrates bind Cyr1 and trigger hyphal growth in Candida albicans. ACS Infectious Diseases. (doi: 10.1021/acsinfecdis.7b00154)

Coldren GA, Barreto C#, Wykoff DD, Morrissey EM, Langley JA, Feller IC, & Chapman SK. 2016. Chronic warming stimulates growth of marsh grasses more than mangroves in a coastal wetland ecotone. Ecology 97(11):3167-3175. doi: 10.1002/ecy.1539.

Herman A#, Serfecz J#, Kinnally A@, Crosby K@, Youngman M, Wykoff D, & Wilson JW. 2016. The bacterial iprA gene is conserved across Enterobacteriaceae, involved in oxidative stress resistance, and influences gene expression in Salmonella enterica serovar Typhimurium. Journal of Bacteriology pii: JB.00144-16.

Iosue CL*, Attanasio N*#, Shaik N@, Neal EM#, Peel M@, Leone SG#, Cali B@, Grannas AM, & Wykoff DD. 2016. Partial decay of thiamine (THI) signal transduction pathway alters growth properties of Candida glabrata. PLoS One 11(3):e0152042 (*authors contributed equally to work).

Orlando KA, Iosue CL, Leone SG@, Davies DL@, & Wykoff DD. 2015. A Paralog of the Phosphomutase-Like Gene Family in Candida glabrata, CgPmu2, Gained Broad-Range Phosphatase Activity Due to a Small Number of Sequence Substitutions. Biochemical Journal 471(2): 187-198.

Estill M#, Kerwin-Iosue CL, & Wykoff DD. 2015. Dissection of the PHO pathway in Schizosaccharomyces pombe using epistasis and the alternate repressor adenine. Current Genetics 61(2): 175-183.

Vile MA, Wieder RK, Scott KD, Vitt DH, Hartsock JA, Iosue CL, Quinn JC, Petix M, Fillingim H, Popma JMA, Dynarski KA, Jackman TR, Albright CM, & Wykoff DD. 2014. N2 -fixation by methanotrophs sustains carbon and nitrogen accumulation in pristine peatlands. Biogeochemistry 121: 317-328.

Corrigan MW@, Kerwin-Iosue CL, Kuczmarski AS@, Amin KB@, & Wykoff DD. 2013. The Fate of Linear DNA in Saccharomyces cerevisiae and Candida glabrata: the Role of Homologous and Non-Homologous End Joining. PLoS ONE 8(7):e69628

Carter-O’Connell I, Peel M.@, Wykoff DD*, & O’Shea EK*. 2012. Genome-Wide Characterization of the Phosphate Starvation Response in Schizosaccharomyces pombe. BMC Genomics 13:697-712. (* = co-corresponding authors)

Kerwin CL & Wykoff DD. 2012. De novo generation of a phosphate regulated promoter in Candida glabrata. FEMS Yeast Research 12:980-989.

Henry TC@, Power JE@, Kerwin CL, Mohammed A@, Weissman JS, Cameron D, Wykoff DD. 2011  Systematic screen of Schizosaccharomyces pombe deletion collection uncovers parallel evolution of the phosphate signal transduction pathway in yeasts. Eukaryotic Cell 10:198-206.

Orkwis BR#, Davies DL@, Kerwin CL, Sanglard D, & Wykoff DD. 2010.  Novel Acid Phosphatase in Candida glabrata Suggests Selective Pressure and Niche Specialization in the Phosphate Signal Transduction Pathway. Genetics 186:885-895.

Kerwin CL# & Wykoff DD. 2009.  Candida glabrata PHO4 is Necessary and Sufficient for Pho2-independent Transcription of Phosphate Starvation Genes. Genetics 182:471-479.

Wykoff DD, Rizvi A, Raser JR, Margolin B, O’Shea EK. 2007. Positive feedback regulates switching of the complement of phosphate transporters in S. cerevisiae. Molecular Cell 27:1005-1013.

Previous to arriving at Villanova University

Chang CW, Moseley JL, Wykoff D, Grossman AR. 2005. The LPB1 Gene Is Important for Acclimation of Chlamydomonas reinhardtii to Phosphorus and Sulfur Deprivation. Plant Physiology 138(1):319-329.

Wykoff DD & O’Shea EK.  2005. Identification of sumoylated proteins in the budding yeast proteome using systematic immunoprecipitations. Molecular & Cellular Proteomics, 4(1):73-83.

Howson R, Huh WK,  Ghaemmaghami S, Falvo JV, Bower K, Belle A, Dephoure N, Wykoff DD, Weissman JS, O’Shea EK.  2005. Construction, Verification, and Experimental Use of Two Epitope-Tagged Collections of Budding Yeast Strains. Comparative & Functional Genomics 6 (1-2):2-16.

Springer M*, Wykoff DD*, Miller N, O’Shea EK.  2003. Partially phosphorylated Pho4 activates transcription of a subset of phosphate-responsive genes. PLOS Biology 1 (2):261-270. (* authors contributed equally to work)

Wykoff DD & O’Shea EK. 2001. Phosphate transport and sensing in Saccharomyces cerevisiae. Genetics 159: 1491-1499.

Wykoff DD, Grossman AR, Weeks DP, Usuda H, Shimogawara K. 1999. Psr1, a nuclear localized protein that regulates phosphorus metabolism in Chlamydomonas. Proceedings of the National Academy of Science USA 96 (26):15336-15341.

Shimogawara K, Wykoff DD, Usuda H, Grossman AR. 1999. Chlamydomonas reinhardtii mutants abnormal in their responses to phosphorus deprivation. Plant Physiology, 120 (3):685-694.

Wykoff DD, Davies JP, Melis A, Grossman AR.  1998. The regulation of photosynthetic electron transport during nutrient deprivation in Chlamydomonas reinhardtii. Plant Physiology, 117 (1):129-139.

Quisel JD, Wykoff DD, Grossman AR.  1996. Biochemical characterization of the extracellular phosphatases produced by phosphorus-deprived Chlamydomonas reinhardtii. Plant Physiology 111(3):839-848.

Britt AB, Chen J-J, Wykoff D, Mitchell, D.  1993. A UV-sensitive mutant of Arabidopsis defective in the repair of pyrimidine-pyrimidinone (6-4) dimers. Science 261(5128):1571-1574.